Silver does not create any antibiotic resistance, it’s old outdated hypotheses that have proven to be unfounded. Silver ions, on the other hand, kill the antibiotic-resistant bacteria that otherwise remain alive. Silver ions also take holes on the biofilm that bacteria build around their colonies and which makes the antibiotic inactive. The latest research shows that silver ions reinforce the antibiotic effect and take care of the antibiotic resistant bacteria. There is some published about the fact that silver increases the effect of antibiotics
Silver enhances antibiotic activity against gram-negative bacteria.
Synergistic effect of silver nanoparticles with the cephalexin antibiotic against the test strains.
With increasing drug-resistance and growing concern regarding the over-prescribing of antibiotics, there has been a resurgent interest in the use of antimicrobial silver. Unlike antibiotics, silver appears to be immune to resistance. Thus, the conjugation of antibiotic with AgNP (Silver nanoparticles) would prevent development of resistance by microbes and enhance the antimicrobial property of the antibiotic. This study is based on the synergistic effect of Cephalexin antibiotic with AgNP. The nanoparticles were evaluated for their increased antimicrobial activities with Cephalexin antibiotic against E.coli and S. aureus. The antibacterial activity of Cephalexin was increased in the presence of AgNPs against test strains. The results showed that the combination of antibiotics with AgNPs have better antimicrobial effects.